Dissertation on opioid addiction

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Nicole D. Windsor , University of Kentucky Follow. Background: Chronic musculoskeletal pain CMP is estimated to affect over million adults annually and is targeted as an instigator of opioid dependence OpD. Opioid medications are often the first response for patients suffering from CMP, but over 10 million people annually admit to misusing opioids. With the opioid epidemic, the healthcare system now has a population of patients who experience CMP with concurrent OpD. This persistent problem creates a perfect storm of fear of movement, low self-efficacy, and physical dysfunction.
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Addictions & Rehabilitation

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"Medication Assisted Treatment and the Three Legged Stool: Medical Prov" by Steven Matt Magrath

Madeline Keane , University of Mississippi Follow. Opioid abuse, leading to addiction and related deaths, has created a chronic epidemic in the United States for the past 30 years. This crisis has sprung from reliance on the prescription of opioid analgesics as the primary method for the management of pain in the s. Due to this systemic minimization of the addictive properties of opioid analgesics, as prescription rates increased, opioid-related mortality rates climbed. This epidemic continues to be pervasive, as opioid-related overdose resulted in 47, deaths in It has been shown that there is potential for the treatment of psychostimulant and opioid addiction by antagonizing the kappa opioid receptor KOR.
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Anterior insula activation restores prosocial behavior in animal model of opioid addiction

Opioid overdose is considered one of the major causes of preventable mortality in the United States. With the expansion of Medicaid, it was speculated that the rate of opioid use disorder would experience a significant decline. The present study explored the trends and causes of OUD in aspect of Medicaid expansion and demographic diversity in the United States. The study was based on a systematic review of evidence-based literature.
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