Prostate cancer phd thesis pdf

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Kasivisvanathan, Veerappan ; The role of MRI-targeted biopsy in the diagnosis of prostate cancer. Doctoral thesis Ph. Introduction: The existing standard of care for the diagnosis of prostate cancer, transrectal ultrasound guided prostate TRUS biopsy, can miss clinically important prostate cancer and over detect clinically unimportant cancer. Results: In a single institutional study, I showed that MRI-TB detected a similar amount of clinically significant cancer to a transperineal prostate biopsy whilst requiring fewer biopsies. It can more efficiently identify men who would benefit from treatment and avoids the diagnosis of men who are less likely to benefit.
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Do a more advanced search ». Author: Charlotte Becker ; Lunds Universitet. Abstract: Human glandular kallikrein 2 hK2 is a predominantly prostate produced protein with many similarities to prostate-specific antigen PSA. Just like for PSA elevated levels of hK2 can be found in men with protate cancer. We created an assay where hK2 in serum could reliably and with negligible cross-reactivity with PSA, be measured down to 0. Gel-filtration of serum with elevated hK2 concentrations showed that the predominant form found in serum was free hK2. We then studied the utility of hK2 measurements in the differentiation of men with benign prostatic hyperplasia BPH from men with prostate cancer PCa.
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Pavlova, Lyudmyla Discovery and validation of novel blood biomarkers of breast and prostate cancer. PhD thesis, University of Essex. Identification of novel biomarkers of breast and prostate cancers to supplement current diagnostic, prognostic and predictive tools is an important clinical need. In a previous investigation conducted in our laboratory, a panel of proteins differentially expressed in white blood cells WBCs of patients with primary and advanced breast cancer BRCA and ABC cohorts, respectively was identified using integrated approaches.
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